Clostridium difficile (C. diff)

Clostridium difficile, or C. diff, is a spore-forming bacterium that can cause diarrhea and colitis (inflammation of the colon) or more serious conditions, such as pseudomembranous colitis. C. diff is most often related to antibiotic use in a health care setting; however, in recent years, these infections have been seen in more people without health care exposures. C. diff infections have become more severe and difficult to treat.