Clostridium difficile, or C. diff, is a spore-forming bacterium that can cause diarrhea and colitis (inflammation of the colon) or more serious conditions such as pseudomembranous colitis. C. diff is most often related to antibiotic use in a healthcare setting.
In recent years, C.diff infections (CDIs) have become more severe and difficult to treat and are seen in people without healthcare exposures traditionally associated with CDI, such as hospital stays.
Clinical Practice Guidelines for Clostridium difficile Infection in Adults (Society for Healthcare Epidemiology of America/ Infectious Disease Society of America [SHEA/IDSA])
Guide to Elimination of Clostridium difficile in Healthcare Settings (Association for Professionals in Infection Control and Epidemiology [APIC])