Cases, Rates and Case Fatality of Invasive Pneumococcal Disease by Age Group:
Denver Metropolitan Area^ and Colorado, 2011

AGE GROUP (years) Cases (Rates) Deaths
EIP^ No. (EIP Rate*) State No. (State rate*) State No. (% of cases)
<1 6 (8.8) 11 (8.3) 1 (9.1)
1 2 (1.9) 3 (1.4) 0 .
2-4 13 (3.8) 24 (3.5) 1 (4.2)
5-17 13 (4.2) 22 (3.2) 0 .
18-34 18 (4.7) 40 (5.4) 0 .
35-49 39 (7.2) 78 (7.3) 4 (5.1)
50-64 87 (18.5) 157 (15.7) 6 (3.8)
65+ 77 (29.7) 148 (25.6) 10 (6.8)
Total 255 (10.2) 484 (9.5) 22 (4.5)

 
 
*Rates are per 100,000 population and based upon 2011-based population estimates, State Demography Office - DOLA
^Emerging Infections Program area: Adams, Arapahoe, Denver, Douglas, and Jefferson counties

 


Rates of Invasive Pneumococcal Disease by County:
Denver Metropolitan Area^, 2011

COUNTY OF RESIDENCE Cases
No. (Rate*)
ADAMS 46 (10.2)
ARAPAHOE 60 (10.3)
DENVER 92 (14.8)
DOUGLAS 15 (5.1)
JEFFERSON 42 (7.8)

 
 
*Rates are per 100,000 population and based upon 2011-based population estimates, State Demography Office - DOLA
^Emerging Infections Program area: Adams, Arapahoe, Denver, Douglas, and Jefferson counties

 


Sterile Sites from which Streptococcus pneumoniae was Isolated:
Denver Metropolitan Area^, 2011

SITE OF ISOLATION No.* (% of cases)
Blood 239 (93.7)
Pleural fluid 12 (4.7)
CSF 11 (4.3)
Joint fluid 3 (1.2)
Peritoneal fluid 2 (0.8)
Pericardial fluid 1 (0.4)
Wound 1 (0.4)

 
*SP was isolated from one site in 237 cases and multiple sites in 18 cases (Total cases=255)
SP was isolated only from blood in 222 cases (87.1%)
^Emerging Infections Program area: Adams, Arapahoe, Denver, Douglas, and Jefferson counties

 


Clinical Syndromes Associated with Invasive Pneumococcal Disease:
Denver Metropolitan Area^, 2011

CLINICAL SYNDROME No.* (% of cases)
Bacteremic pneumonia 187 (73.3)
Bacteremia only 29 (11.4)
Meningitis 16 (6.3)
Empyema 14 (5.5)
Otitis media 6 (2.4)
Septic arthritis 4 (1.6)
Endocarditis 4 (1.6)
Epiglottitis 3 (1.2)
Abscess 3 (1.2)
Peritonitis 3 (1.2)
Cellulitis 1 (0.4)
Pericarditis 1 (0.4)
Osteomyelitis 1 (0.4)

 
 
*Some cases had more than one syndrome (Total cases=255)
^Emerging Infections Program area: Adams, Arapahoe, Denver, Douglas, and Jefferson counties

 


Underlying Conditions Associated with Invasive Pneumococcal Disease:
Denver Metropolitan Area^, 2011

UNDERLYING CONDITION No.* (% of cases)
Current Smoker 67 (26.3)
Emphysema/COPD 56 (22.0)
Diabetes 34 (13.3)
Asthma 26 (10.2)
Alcohol Abuse 26 (10.2)
Atherosclerotic Cardiovascular Disease 21 (8.2)
Heart Failure/CHF 16 (6.3)
Immunosuppressive Therapy 15 (5.9)
HIV 14 (5.5)
Obesity 13 (5.1)
AIDS 8 (3.1)
Renal Failure/Dialysis 7 (2.7)
Cirrhosis/Liver Failure 7 (2.7)
Cerebral Vascular Accident/Stroke 6 (2.4)
Multiple Myeloma 5 (2.0)
Leukemia 5 (2.0)
Systemic Lupus Erythematosus 4 (1.6)
Immunoglobulin Deficiency 2 (0.8)
Hodgkin"s Disease 2 (0.8)
Intravenous Drug Use 2 (0.8)
Splenectomy/Asplenia 1 (0.4)
Nephrotic Syndrome 1 (0.4)
Complement deficiency 1 (0.4)
Deaf/Hearing loss 1 (0.4)

 
*100 cases had more than one underlying condition
48 (18.8%) had no underlying conditions; 3 cases were unknown (Total cases=255)
^Emerging Infections Program area: Adams, Arapahoe, Denver, Douglas, and Jefferson counties

 


Invasive Pneumococcal Disease Serotypes:
Denver Metropolitan Area^, 2011

Serotype No.* (% of isolates)
07F 18 (29.0)
003 9 (14.5)
19A 8 (12.9)
22F 5 (8.0)
09N 4 (6.4)
06C 4 (6.4)
33F 2 (3.2)
12F 2 (3.2)
09V 2 (3.2)
35B 2 (3.2)
15B 1 (1.6)
008 1 (1.6)
038 1 (1.6)
11A 1 (1.6)
23A 1 (1.6)
15A 1 (1.6)
Total 62 (100.0)

 
*Based upon reference lab testing of 62 (24.3%) isolates (Total cases=255)
Testing performed by the Centers for Disease Control and Prevention: Atlanta, GA
^Emerging Infections Program area: Adams, Arapahoe, Denver, Douglas, and Jefferson counties