Cases, Rates and Case Fatality of Invasive Pneumococcal Disease by Age Group:
Denver Metropolitan Area^ and Colorado, 2010

AGE GROUP (years) Cases (Rates) Deaths
EIP^ No. (EIP Rate*) State No. (State rate*) State No. (% of cases)
<1 16 (23.4) 21 (15.7) 0 .
1 7 (6.6) 13 (6.2) 2 (15.4)
2-4 13 (3.8) 26 (3.8) 0 .
5-17 10 (3.2) 22 (3.2) 0 .
18-34 18 (4.7) 40 (5.5) 3 (7.5)
35-49 67 (12.4) 107 (10.0) 5 (4.7)
50-64 89 (19.6) 158 (16.2) 10 (6.3)
65+ 85 (34.4) 160 (28.8) 13 (8.1)
Total 305 (12.5) 547 (10.8) 33 (6.0)

Statewide includes 1 probable case
 
*Rates are per 100,000 population and based upon 2011-based population estimates, State Demography Office - DOLA
^Emerging Infections Program area: Adams, Arapahoe, Denver, Douglas, and Jefferson counties

 


Rates of Invasive Pneumococcal Disease by County:
Denver Metropolitan Area^, 2010

COUNTY OF RESIDENCE Cases
No. (Rate*)
ADAMS 57 (12.8)
ARAPAHOE 61 (10.6)
DENVER 98 (16.2)
DOUGLAS 20 (7.0)
JEFFERSON 70 (13.1)

 
 
*Rates are per 100,000 population and based upon 2011-based population estimates, State Demography Office - DOLA
^Emerging Infections Program area: Adams, Arapahoe, Denver, Douglas, and Jefferson counties

 


Sterile Sites from which Streptococcus pneumoniae was Isolated:
Denver Metropolitan Area^, 2010

SITE OF ISOLATION No.* (% of cases)
Blood 280 (91.5)
CSF 13 (4.2)
Pleural fluid 13 (4.2)
Joint fluid 6 (2.0)
Peritoneal fluid 1 (0.3)
Bone 1 (0.3)
Middle ear 1 (0.3)
Body site 1 (0.3)

 
*SP was isolated from one site in 291 cases and multiple sites in 15 cases (Total cases=306)
SP was isolated only from blood in 265 cases (86.6%)
^Emerging Infections Program area: Adams, Arapahoe, Denver, Douglas, and Jefferson counties

 


Clinical Syndromes Associated with Invasive Pneumococcal Disease:
Denver Metropolitan Area^, 2010

CLINICAL SYNDROME No.* (% of cases)
Bacteremic pneumonia 219 (71.6)
Bacteremia only 44 (14.4)
Meningitis 18 (5.9)
Empyema 12 (3.9)
Septic arthritis 6 (2.0)
Otitis media 5 (1.6)
Cellulitis 5 (1.6)
Abscess 5 (1.6)
Osteomyelitis 3 (1.0)
Epiglottitis 2 (0.7)
Peritonitis 2 (0.7)
Endocarditis 1 (0.3)

 
 
*Some cases had more than one syndrome (Total cases=306)
^Emerging Infections Program area: Adams, Arapahoe, Denver, Douglas, and Jefferson counties

 


Underlying Conditions Associated with Invasive Pneumococcal Disease:
Denver Metropolitan Area^, 2010

UNDERLYING CONDITION No.* (% of cases)
Current Smoker 80 (26.1)
Emphysema/COPD 56 (18.3)
Diabetes 40 (13.1)
Alcohol Abuse 33 (10.8)
Immunosuppressive Therapy 28 (9.2)
Asthma 21 (6.9)
Atherosclerotic Cardiovascular Disease 19 (6.2)
Obesity 19 (6.2)
Heart Failure/CHF 18 (5.9)
Systemic Lupus Erythematosus 11 (3.6)
Cirrhosis/Liver Failure 10 (3.3)
Cerebral Vascular Accident/Stroke 9 (2.9)
HIV 8 (2.6)
Hodgkin"s Disease 5 (1.6)
Leukemia 4 (1.3)
Renal Failure/Dialysis 4 (1.3)
Intravenous Drug Use 4 (1.3)
Multiple Myeloma 3 (1.0)
AIDS 3 (1.0)
Splenectomy/Asplenia 1 (0.3)
Immunoglobulin Deficiency 1 (0.3)

 
*118 cases had more than one underlying condition
74 (24.2%) had no underlying conditions; 3 cases were unknown (Total cases=306)
^Emerging Infections Program area: Adams, Arapahoe, Denver, Douglas, and Jefferson counties

 


Invasive Pneumococcal Disease Serotypes:
Denver Metropolitan Area^, 2010

Serotype No.* (% of isolates)
07F 72 (26.9)
19A 33 (12.3)
003 30 (11.2)
22F 24 (8.9)
06C 17 (6.3)
008 14 (5.2)
15A 11 (4.1)
09N 10 (3.7)
11A 8 (2.9)
038 6 (2.2)
23B 5 (1.8)
06A 4 (1.4)
23A 4 (1.4)
031 3 (1.1)
35B 3 (1.1)
16F 2 (0.7)
12F 2 (0.7)
15B 2 (0.7)
15C 2 (0.7)
034 2 (0.7)
33F 2 (0.7)
09V 1 (0.3)
NT 1 (0.3)
35F 1 (0.3)
07C 1 (0.3)
005 1 (0.3)
23F 1 (0.3)
10A 1 (0.3)
004 1 (0.3)
19F 1 (0.3)
037 1 (0.3)
020 1 (0.3)
Total 267 (100.0)

 
*Based upon reference lab testing of 267 (87.3%) isolates (Total cases=306)
Testing performed by the Centers for Disease Control and Prevention: Atlanta, GA
^Emerging Infections Program area: Adams, Arapahoe, Denver, Douglas, and Jefferson counties